Article
Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases.
Antiviral therapy - 1 Jan 2006
Gerolami Rene, Bourliere Marc, Colson Philippe, Halfon Philippe, Borentain Patrick, Henry Mireille, Botta Daniele, Thibault Vincent, Khiri Hacene, Tamalet Catherine
Abstract excerpt
Development of hepatitis B virus (HBV)-resistant strains following nucleos(t)ide analogue treatment is a major concern. The A181V mutation within the reverse transcriptase (RT) of HBV has been shown to be associated with HBV resistance to adefovir dipivoxil (ADV), and its level of sensitivity to other nucleos(t)ide analogues is an important issue. This article reports two cases of chronically HBV infected...
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