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Article

Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure.

Journal of hepatology - 1 May 2008

Villet Stéphanie, Pichoud Christian, Billioud Gaëtan, Barraud Luc, Durantel Sandra, Trépo Christian, Zoulim Fabien

Abstract excerpt

BACKGROUND/AIMS: Recent clinical observations reported the occurrence of amino acid substitutions at position 181 of the HBV polymerase, associated with a viral breakthrough under lamivudine or adefovir therapy. In this study, we characterized the main variants harboring the rtA181T/V mutation isolated from 10 consecutive patients who developed lamivudine and/or adefovir resistance. METHODS: We performed a clonal...

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Source

Identifiers

PMID: 18331765
DOI: 10.1016/j.jhep.2008.01.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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