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Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance

2019-05-13

Abstract excerpt

<h4>Background & Aims</h4> Tenofovir disoproxil fumarate (TDF) imposes a high genetic barrier to drug resistance and potently inhibits replication of multidrug-resistant hepatitis B virus (MDR HBV) and few clinical cases with confirmed TDF-resistance have been reported to date. We reported a quadruple mutant which showed moderate resistant to TDF. <h4>Methods and results</h4> Viral rebound was reported in a pati...

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Literature Corpus work
c411d462-64c0-5251-8fe2-baa4b98d8bd5
DOI
10.1101/632984
Open publication

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Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistanceDOI 10.1101/632984
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