Article
Antiviral efficacy of entecavir versus entecavir plus adefovir for hepatitis B virus rtA181V/T mutants alone.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association - 1 Jan 2000
Oh Myung Jin, Lee Heon Ju
Abstract excerpt
BACKGROUND/AIMS: Hepatitis B virus (HBV) rtA181V/T mutants developed by long-term nucleos(t) ide analogue therapy are known to present cross-resistance for other nucleos (t) ide analogues, except entecavir (ETV). Some studies reported that HBV rtA181V/T mutants could induce cross-resistance to ETV and showed incomplete response as well as persistence of HBV DNA, despite rescue therapy by ETV. This study aimed to...
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