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Article

Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient.

Journal of hepatology - 1 Mar 2007

Villet Stéphanie, Ollivet Aurélie, Pichoud Christian, Barraud Luc, Villeneuve Jean-Pierre, Trépo Christian, Zoulim Fabien

Abstract excerpt

BACKGROUND/AIMS: Complex mutants may be selected under sequential anti-VHB pressures. We analyzed the genotypic and phenotypic evolution of the viral quasi-species of a patient who developed resistance to entecavir following lamivudine breakthrough. METHODS: The polymerase gene was amplified, cloned and sequenced at different time points. Hepatoma cell lines were transfected to compare the replication capacity of...

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Identifiers

PMID: 17239478
DOI: 10.1016/j.jhep.2006.11.016

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