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Article

Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.

BMC cancer - 21 Sept 2011

Yeh Chau-Ting, Chen Tiffany, Hsu Chao-Wei, Chen Yi-Cheng, Lai Ming-Wei, Liang Kung-Hao, Chen Tse-Ching

Abstract excerpt

BACKGROUND: Development of the hepatitis B virus (HBV) rtA181T/sW172* mutant could occur during prolonged lamivudine (LAM) therapy, conferring cross resistance to adefovir. Recent studies demonstrated an increased oncogenic potential of this mutant in NIH3T3 cells. In this study, we aimed to investigate the clinical significance of this finding. METHODS: Serum samples from 123 LAM-resistant chronic hepatitis B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21933446
DOI: 10.1186/1471-2407-11-398
PMCID: PMC3184121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.PMID 21933446Read ↗

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