Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of cyclooxygenase-2 genetic variant with cardiovascular disease

5 May 2014

Abstract excerpt

AIM: A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been associated with decreased COX-2 activity and a decreased risk of cardiovascular disease (CVD). However, this genetic association and the role of COX-2 in CVD remain controversial. METHODS AND RESULTS: The association of rs20417 with CVD was prospectively explored in 49 232 subjects (ACTIVE-A, CURE, epiDREAM/DREAM, ONTARGET, RE-LY,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eicosanoids and Hypertension Pharmacology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammatory mediators and NSAID effects

Share to Pharmacogenetics and Drug Metabolism

Source

Identifiers

PMID: 24796340
DOI: 10.1093/eurheartj/ehu168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of cyclooxygenase-2 genetic variant with cardiovascular diseasePMID 24796340Read ↗

A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease.Semantic proximity Read ↗

Pharmacogenomics of cyclooxygenases.Semantic proximity Read ↗

Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).Semantic proximity Read ↗

Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.Semantic proximity Read ↗

Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors.Semantic proximity Read ↗

Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach.Semantic proximity Read ↗

Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease.Semantic proximity Read ↗

Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).Semantic proximity Read ↗

Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.Semantic proximity Read ↗

Prostacyclin synthase gene: genetic polymorphisms and prevention of some cardiovascular diseases.Semantic proximity Read ↗

Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G−765C polymorphism in African-Americans: The Atherosclerosis Risk in Communities StudySemantic proximity Read ↗

Frequency, risk factors, prognosis, and genetic polymorphism of the cyclooxygenase-1 gene for aspirin resistance in elderly Chinese patients with cardiovascular disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.