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Article

Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila.

The Journal of biological chemistry - 13 Apr 2007

Umeda-Kameyama Yumi, Tsuda Manabu, Ohkura Chiaki, Matsuo Takashi, Namba Yoshio, Ohuchi Yasuyoshi, Aigaki Toshiro

Abstract excerpt

Parkin-associated endothelin receptor-like receptor (Pael-R) is a substrate of the E3 ubiquitin ligase Parkin, which has been implicated in the pathogenesis of Parkinson disease. Misexpression of human Pael-R in Drosophila has been shown to induce selective loss of dopaminergic neurons, a symptom of Parkinson disease. Using this model, we investigated whether thioredoxin (TRX), an evolutionarily conserved...

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PMID: 17301052
DOI: 10.1074/jbc.M700937200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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