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Article

Absence of pretaporter restrains features of the parkin phenotype in Drosophila.

Experimental neurology - 1 Jan 2025

Silvera María Constanza, Cantera Rafael, Ferreiro María José

Abstract excerpt

BACKGROUND: Scientific research based on model organisms can help to understand the biology of Parkinson's Disease, the second most prevalent neurodegenerative disease. Drosophila melanogaster mutant for the gene parkin, homologous to human's PARK2, exhibit well-characterized phenotypes including loss of dopaminergic neurons, lower survival and motor defects. Through the transcriptomic analysis of an exceptional...

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PMID: 39393670
DOI: 10.1016/j.expneurol.2024.114997

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