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Article

Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models

1 Jul 2025

Abstract excerpt

Ergothioneine (ET) is a naturally occurring thiol/thione that possesses several cytoprotective properties. Multiple studies suggest a potential neuroprotective role for ET. Here, we show in various Parkinson's disease (PD) models that ET is indeed neuroprotective. Firstly, using Drosophila genetic PD models, we demonstrated that ET treatment ameliorates the pathological phenotypes of parkin and LRRK2 PD mutant...

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PMID: 40696819
DOI: 10.1111/jnc.70168

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