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Article

Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models.

Journal of neurochemistry - 1 Jul 2025

Tng Teddy J W, Leow Damien M K, Goh Geraldine, Wang Ziyin, Liu Yanmei, Tang Richard M Y, Lai Kate C L, Basil Adeline H, Choong Huey Ching, Goh Wilson W B, Cheah Irwin K, Ong Wei-Yi, Halliwell Barry, Lim Kah-Leong

Abstract excerpt

Ergothioneine (ET) is a naturally occurring thiol/thione that possesses several cytoprotective properties. Multiple studies suggest a potential neuroprotective role for ET. Here, we show in various Parkinson's disease (PD) models that ET is indeed neuroprotective. Firstly, using Drosophila genetic PD models, we demonstrated that ET treatment ameliorates the pathological phenotypes of parkin and LRRK2 PD mutant...

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Identifiers

PMID: 40696819
DOI: 10.1111/jnc.70168
PMCID: PMC12284465

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