Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2009

Thomas Kate, Rafiq Sajjad, Frayling Timothy M, Ebrahim Shah, Kumari Meena, Gallacher John, Ferrucci Luigi, Bandinelli Stefania, Wallace Robert B, Melzer David, Martin Richard M, Ben-Shlomo Yoav

Abstract excerpt

BACKGROUND: Levels of the proinflammatory cytokine interleukin-18 (IL-18) are raised in old age and are associated with reduced physical functioning. Previous studies have indicated that the C allele of the rs5744256 polymorphism in the IL-18 gene is strongly associated with reduced circulating I...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Interleukin-18

Share to Polymorphism, Single Nucleotide

Share to Reproducibility of Results

Share to Walking

Source

Open in PubMed Open full text

Identifiers

PMID: 19633236
DOI: 10.1093/gerona/glp092
PMCID: PMC2981454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19633236-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis.PMID 19633236Read ↗

An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people.Semantic proximity Read ↗

TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women.Semantic proximity Read ↗

Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing.Semantic proximity Read ↗

Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial.Semantic proximity Read ↗

Interleukin 10 (IL10) promoter region polymorphism is associated with IL10 serum concentrations and processing speed in healthy community-dwelling older adults.Semantic proximity Read ↗

Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis.Semantic proximity Read ↗

Effects of 174 G/C polymorphism in the promoter region of the interleukin-6 gene on plasma IL-6 levels and muscle strength in elderly women.Semantic proximity Read ↗

Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals.Semantic proximity Read ↗

Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis.Semantic proximity Read ↗

Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs.Semantic proximity Read ↗

IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women.Semantic proximity Read ↗

Association and Interaction Effects of Interleukin-12 Related Genes and Physical Activity on Cognitive Aging in Old Adults in the Taiwanese PopulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.