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Article

Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs.

GeroScience - 1 Feb 2023

Brunt Vienna E, Ikoba Akpevweoghene P, Ziemba Brian P, Ballak Dov B, Hoischen Alexander, Dinarello Charles A, Ehringer Marissa A, Seals Douglas R

Abstract excerpt

Aging is characterized by declines in physiological function that increase risk of age-associated diseases and limit healthspan, mediated in part by chronic low-grade inflammation. Interleukin (IL)-37 suppresses inflammation in pathophysiological states but has not been studied in the context of aging in otherwise healthy humans. Thus, we investigated associations between IL-37 and markers of healthspan in 271...

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Identifiers

PMID: 35622271
DOI: 10.1007/s11357-022-00587-3
PMCID: PMC9137444

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