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Article

Clinical significance of TP53 mutations in adult T-cell leukemia/lymphoma.

British journal of haematology - 1 Nov 2021

Sakamoto Yuma, Ishida Takashi, Masaki Ayako, Murase Takayuki, Takeshita Morishige, Muto Reiji, Iwasaki Hiromi, Ito Asahi, Kusumoto Shigeru, Nakano Nobuaki, Tokunaga Masahito, Yonekura Kentaro, Tashiro Yukie, Iida Shinsuke, Utsunomiya Atae, Ueda Ryuzo, Inagaki Hiroshi

Abstract excerpt

Adult T-cell leukaemia/lymphoma (ATL) patients have a poor prognosis. Here, we investigated the impact of TP53 gene mutations on prognosis of ATL treated in different ways. Among 177 patients, we identified 47 single nucleotide variants or insertion-deletions (SNVs/indels) of the TP53 gene in 37 individuals. TP53 copy number variations (CNVs) were observed in 38 patients. Altogether, 67 of 177 patients harboured...

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Identifiers

PMID: 34405395
DOI: 10.1111/bjh.17749
PMCID: PMC9291095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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