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Article

Aberrant regulation of the MRP3 gene in non-small cell lung carcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2012

Mahaffey Christopher M, Mahaffey Nichole C, Holland William, Zhang Hongqiao, Gandara David R, Mack Philip C, Forman Henry Jay

Abstract excerpt

INTRODUCTION: Multidrug-resistant protein-3 (MRP3), a membrane-bound transporter, facilitates efflux of toxic compounds, including certain chemotherapies, out of cells. Aberrant MRP3 expression has been linked to drug resistance in non-small cell lung carcinoma (NSCLC). We sought to determine if tumor MRP3 expression patterns correlate with the mutational status of upstream regulators, including nuclear factor...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intracellular Signaling Peptides and Proteins

Share to Kelch-Like ECH-Associated Protein 1

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Identifiers

PMID: 22089114
DOI: 10.1097/JTO.0b013e318233d753
PMCID: PMC3241903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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