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Article

Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element.

The Journal of pharmacology and experimental therapeutics - 1 Oct 2016

Sasaki Takamitsu, Inami Keita, Numata Yoshihiro, Funakoshi Kodai, Yoshida Midori, Kumagai Takeshi, Kanno Shuichi, Matsui Satomi, Toriyabe Takayoshi, Yamazoe Yasushi, Yoshinari Kouichi, Nagata Kiyoshi

Abstract excerpt

Multidrug resistance-associated protein 3 (MRP3) is a basolaterally localized transporter in the liver and contributes to the transport of various metabolites such as conjugates of endogenous compounds and drugs from hepatocytes. MRP3 expression in the human liver is low under normal physiologic conditions but is induced by drug treatment. Although several studies have identified a region necessary for the basal...

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PMID: 27507784
DOI: 10.1124/jpet.115.231589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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