Article
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
Molecular psychiatry - 1 Apr 2014
Li M, Luo X-J, Rietschel M, Lewis C M, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson P M, Cichon S, Nöthen M M, Schulze T G, Sullivan P F, Bergen S E, Donohoe G, Morris D W, Hargreaves A, Gill M, Corvin A, Hultman C, Toga A W, Shi L, Lin Q, Shi H, Gan L, Meyer-Lindenberg A, Czamara D, Henry C, Etain B, Bis J C, Ikram M A, Fornage M, Debette S, Launer L J, Seshadri S, Erk S, Walter H, Heinz A, Bellivier F, Stein J L, Medland S E, Arias Vasquez A, Hibar D P, Franke B, Martin N G, Wright M J, Su B
Abstract excerpt
Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here,...
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