Article
Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study.
Archives of general psychiatry - 1 Jun 2007
Perlis Roy H, Purcell Shaun, Fava Maurizio, Fagerness Jesen, Rush A John, Trivedi Madhukar H, Smoller Jordan W
Abstract excerpt
CONTEXT: A small subset of patients with depression exhibit new or worsening suicidal thoughts or behavior during short-term treatment with antidepressants. Because cyclic adenosine monophosphate response element binding (CREB) protein has been implicated in both antidepressant mechanisms and suicide, the CREB1 gene represents a gene that possibly influences the risk for treatment-emergent suicidality. OBJECTIVE:...
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