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Article

Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.

The Biochemical journal - 1 Jun 2007

Biondi Christine A, Das Debipriya, Howell Michael, Islam Ayesha, Bikoff Elizabeth K, Hill Caroline S, Robertson Elizabeth J

Abstract excerpt

Smad4 in partnership with R-Smads (receptor-regulated Smads) activates TGF-beta (transforming growth factor-beta)-dependent signalling pathways essential for early mouse development. Smad4 null embryos die shortly after implantation due to severe defects in cell proliferation and visceral endoderm differentiation. In the basal state, Smad4 undergoes continuous shuttling between the cytoplasm and the nucleus due...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17300215
DOI: 10.1042/BJ20061830
PMCID: PMC1868808

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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