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Article

A novel nuclear export signal in Smad1 is essential for its signaling activity.

The Journal of biological chemistry - 5 Sept 2003

Xiao Zhan, Brownawell Amy M, Macara Ian G, Lodish Harvey F

Abstract excerpt

To investigate the subcellular distributions of Smad proteins, the intracellular mediators of transforming growth factor-beta family cytokines, we examined their sequences for nuclear export signals (NES). We found a leucine-rich NES-like motif (termed NES2) in the central linker region of the receptor-regulated Smads that is absent from the other two classes of Smads (Co-Smads and I-Smads). In microinjection...

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Identifiers

PMID: 12821673
DOI: 10.1074/jbc.M301596200

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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