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Article

A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2006

Chen Yijing, Yee Della, Magnuson Terry

Abstract excerpt

Smad4 is a key signal transducer of the transforming growth factor-beta (TGF-beta) superfamily of growth factors that are critical regulators of embryonic patterning and adult tissue homeostasis. The biological activity of the TGF-beta signaling is tightly controlled at multiple levels, including the abundance of SMAD4 proteins. We previously recovered a novel allele of Smad4 in a gene-based screen in...

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Identifiers

PMID: 16518688
DOI: 10.1007/s00335-005-0074-3

Genes

SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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