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Article

Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells.

The Journal of experimental medicine - 9 Jul 2007

Leung Cindy G, Xu Yanfei, Mularski Bretton, Liu Hui, Gurbuxani Sandeep, Crispino John D

Abstract excerpt

Survivin, which is the smallest member of the inhibitor of apoptosis protein (IAP) family, is a chromosomal passenger protein that mediates the spindle assembly checkpoint and cytokinesis, and also functions as an inhibitor of apoptosis. Frequently overexpressed in human cancers and not expressed in most adult tissues, survivin has been proposed as an attractive target for anticancer therapies and, in some cases,...

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Identifiers

PMID: 17576776
DOI: 10.1084/jem.20062395
PMCID: PMC2118642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells.PMID 17576776Read ↗

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