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Article

Inhibitor of apoptosis protein survivin regulates vascular injury.

Nature medicine - 1 Sept 2002

Blanc-Brude Olivier P, Yu Jun, Simosa Hector, Conte Michael S, Sessa William C, Altieri Dario C

Abstract excerpt

Survivin (also termed Birc5) belongs to the family of genes known as inhibitors of apoptosis, and it has been implicated in both prevention of cell death and control of mitosis. The survivin pathway is exploited in cancer, but its potential role in vascular injury is unknown. Here, we show that balloon-mediated arterial injury in rabbits resulted in expression of survivin in vascular cells. Serum or PDGF-AB...

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Source

Identifiers

PMID: 12172543
DOI: 10.1038/nm750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibitor of apoptosis protein survivin regulates vascular injury.PMID 12172543Read ↗

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Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular smooth muscle cellsSemantic proximity Read ↗

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.Semantic proximity Read ↗

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.Semantic proximity Read ↗

Lessons learned from cancer may help in the treatment of pulmonary hypertension.Semantic proximity Read ↗

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells.Semantic proximity Read ↗

Survivin: A Bifunctional Inhibitor of Apoptosis ProteinSemantic proximity Read ↗

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