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Article

Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.

Cancer science - 1 Feb 2007

Tamura Ai, Wakabayashi Kanako, Onishi Yuko, Takeda Misako, Ikegami Yoji, Sawada Seigo, Tsuji Masahisa, Matsuda Yoichi, Ishikawa Toshihisa

Abstract excerpt

Impacts of genetic polymorphisms of the ATP-binding cassette (ABC) transporter BCRP/MXR1/ABCP (ABCG2) on drug response have been implicated; however, the hitherto reported data involve some inconsistencies. To re-evaluate the effect of single nucleotide polymorphisms (SNP) of ABCG2 in vitro, we created a total of seven variant cDNAs (V12M, Q141K, F208S, S248P, F431L, S441N and F489L) by site-directed mutagenesis...

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Identifiers

PMID: 17297656
DOI: 10.1111/j.1349-7006.2006.00371.x
PMCID: PMC11158858

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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