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Article

Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2.

The Biochemical journal - 1 May 2008

Nakagawa Hiroshi, Tamura Ai, Wakabayashi Kanako, Hoshijima Kazuyuki, Komada Masayuki, Yoshida Takashi, Kometani Satoshi, Matsubara Takayoshi, Mikuriya Kenta, Ishikawa Toshihisa

Abstract excerpt

Clinical relevance is implicated between the genetic polymorphisms of the ABC (ATP-binding cassette) transporter ABCG2 (ABC subfamily G, member 2) and the individual differences in drug response. We expressed a total of seven non-synonymous SNP (single nucleotide polymorphism) variants in Flp-In-293 cells by using the Flp (flippase) recombinase system. Of these, ABCG2 F208S and S441N variants were found to be...

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Identifiers

PMID: 18237272
DOI: 10.1042/BJ20071229

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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