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Article

Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.

Pharmaceutical research - 1 Feb 2009

Furukawa Tomoka, Wakabayashi Kanako, Tamura Ai, Nakagawa Hiroshi, Morishima Yoshihiro, Osawa Yoichi, Ishikawa Toshihisa

Abstract excerpt

PURPOSE: Single nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC) transporter ABCG2 gene have been suggested to be a significant factor in patients' responses to medication and/or the risk of diseases. We aimed to evaluate the impact of the major non-synonymous SNP Q141K on lysoso...

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Source

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Identifiers

PMID: 18958403
DOI: 10.1007/s11095-008-9752-7
PMCID: PMC2628956

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18958403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.PMID 18958403Read ↗

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