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Article

Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells.

Human mutation - 1 Apr 2012

Arlanov Rudolf, Porter Andrew, Strand Dennis, Brough Rachel, Karpova Darja, Kerb Reinhold, Wojnowski Leszek, Schwab Matthias, Lang Thomas

Abstract excerpt

The multidrug resistance-associated protein 2 (MRP2/ABCC2) is involved in the efflux of endogenous and xenobiotic substrates, including several anticancer and antiviral drugs. The functional consequences of ABCC2 protein variants remain inconsistent, which may be due to shortcomings of the in vit...

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Source

Identifiers

PMID: 22290738
DOI: 10.1002/humu.22041

Genes

ABCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22290738-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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