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Article

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 1995

Miller R D, Hogg J, Ozaki J H, Gell D, Jackson S P, Riblet R

Abstract excerpt

The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the...

Topics

Animals
Base Sequence
Chromosome Mapping
Crosses, Genetic
DNA-Activated Protein Kinase
DNA-Binding Proteins
Mice
Mice, SCID
Molecular Sequence Data
Muridae
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Protein Serine-Threonine Kinases

Recombination, Genetic

Severe Combined Immunodeficiency

Source

Open in PubMed Open full text

Identifiers

PMID: 7479885
DOI: 10.1073/pnas.92.23.10792
PMCID: PMC40698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7479885-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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