Article
APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers.
Neurology - 9 May 2006
Burwick R M, Ramsay P P, Haines J L, Hauser S L, Oksenberg J R, Pericak-Vance M A, Schmidt S, Compston A, Sawcer S, Cittadella R, Savettieri G, Quattrone A, Polman C H, Uitdehaag B M J, Zwemmer J N P, Hawkins C P, Ollier W E R, Weatherby S, Enzinger C, Fazekas F, Schmidt H, Schmidt R, Hillert J, Masterman T, Hogh P, Niino M, Kikuchi S, Maciel P, Santos M, Rio M E, Kwiecinski H, Zakrzewska-Pniewska B, Evangelou N, Palace J, Barcellos L F
Abstract excerpt
BACKGROUND: Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and families genotyped for the APOE epsilon polymorphism. METHODS: Studies of MS and APOE were identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.