Article
Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil.
Memorias do Instituto Oswaldo Cruz - 1 Feb 2007
Cardoso Rosilene Fressatti, Cardoso Marco Antonio, Leite Clarice Queico Fujimura, Sato Daisy Nakamura, Mamizuka Elsa Masae, Hirata Rosário Dominguez Crespo, de Mello Fernando Fiúza, Hirata Mario Hiroyuki
Abstract excerpt
Resistance in Mycobacterium tuberculosis to isoniazid (INH) is caused by mutations in the catalase-peroxidase gene (katG), and within the inhA promoter and/or in structural gene. A small percentage (approximately 10%) of INH-resistant strains do not present mutations in both of these loci. Other genes have been associated with INH resistance including the gene encoding for NADH dehydrogenase (ndh). Here we report...
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