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Article

Mechanisms for isoniazid action and resistance.

Novartis Foundation symposium - 1 Jan 1998

Miesel L, Rozwarski D A, Sacchettini J C, Jacobs W R

Abstract excerpt

Isoniazid is the most widely used antituberculosis drug. Genetic studies in Mycobacterium smegmatis identified the inhA-encoded, NADH-dependent enoyl acyl carrier protein reductase as the primary target for this drug. A reactive form of isoniazid inhibits InhA by reacting with the NAD(H) cofactor...

Topics

Bacterial Proteins
Drug Resistance, Microbial
Isoniazid
Mutation
Mycobacterium smegmatis
Mycolic Acids
NAD
NADH Dehydrogenase
Oxidoreductases
Peroxidases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9949810
DOI: 10.1002/0470846526.ch15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9949810-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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