Article
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
Antimicrobial agents and chemotherapy - 1 Feb 2005
Vilchèze Catherine, Weisbrod Torin R, Chen Bing, Kremer Laurent, Hazbón Manzour H, Wang Feng, Alland David, Sacchettini James C, Jacobs William R
Abstract excerpt
The front-line antituberculosis drug isoniazid (INH) and the related drug ethionamide (ETH) are prodrugs that upon activation inhibit the synthesis of mycolic acids, leading to bactericidal activity. Coresistance to INH and ETH can be mediated by dominant mutations in the target gene inhA, encoding an enoyl-ACP reductase, or by recessive mutations in ndh, encoding a type II NADH dehydrogenase (NdhII). To address...
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