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Article

Elevated postmortem striatal t-DARPP expression in schizophrenia and associations with DRD2/ANKK1 polymorphism.

Progress in neuro-psychopharmacology & biological psychiatry - 4 Aug 2014

Kunii Yasuto, Miura Itaru, Matsumoto Junya, Hino Mizuki, Wada Akira, Niwa Shin-ichi, Nawa Hiroyuki, Sakai Miwako, Someya Toshiyuki, Takahashi Hitoshi, Kakita Akiyoshi, Yabe Hirooki

Abstract excerpt

BACKGROUND: Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) and calcineurin (CaN) have been implicated in the pathogenesis of schizophrenia because they function as molecular integrators of dopamine and glutamate signaling. DARPP-32 and CaN are mainly expressed in the caudate nucleus and putamen; however, a few postmortem brain studies have focused on DARPP-32 expression in...

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Identifiers

PMID: 24704945
DOI: 10.1016/j.pnpbp.2014.03.014

Genes

DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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