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Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder.

Schizophrenia research - 1 Mar 2008

Yoshimi Akira, Takahashi Nagahide, Saito Shinichi, Ito Yoshihito, Aleksic Branko, Usui Hinako, Kawamura Yukiko, Waki Yukari, Yoshikawa Takeo, Kato Tadafumi, Iwata Nakao, Inada Toshiya, Noda Yukihiro, Ozaki Norio

Abstract excerpt

Several lines of evidence, including genome-wide linkage scans and postmortem brain studies of patients with schizophrenia or bipolar disorder, have suggested that DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa), a key regulatory molecule in the dopaminergic signaling pathway, is involved in these disorders. After evaluating the linkage disequilibrium pattern of the gene encoding DARPP-32 (PPP1R1B;...

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PMID: 18055181
DOI: 10.1016/j.schres.2007.10.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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