Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.

Molecular and cellular biology - 1 Apr 2007

Zheng Li, Dai Huifang, Qiu Junzhuan, Huang Qin, Shen Binghui

Abstract excerpt

The interaction between flap endonuclease 1 (FEN-1) and proliferation cell nuclear antigen (PCNA) is critical for faithful and efficient Okazaki fragment maturation. In a living cell, this interaction is probably important for PCNA to load FEN-1 to the replication fork, to coordinate the sequential functions of FEN-1 and other enzymes, and to stimulate its enzyme activity. The FEN-1/PCNA interaction is mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Flap Endonucleases

Share to Mice, Mutant Strains

Share to Pancytopenia

Share to Proliferating Cell Nuclear Antigen

Share to Stillbirth

Source

Open in PubMed Open full text

Identifiers

PMID: 17283043
DOI: 10.1128/MCB.01652-06
PMCID: PMC1899923

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.PMID 17283043Read ↗

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.Semantic proximity Read ↗

XPF mediates 3’ flap processing for FEN1-independent Okazaki fragment maturationSemantic proximity Read ↗

Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region.Semantic proximity Read ↗

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.Semantic proximity Read ↗

Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Semantic proximity Read ↗

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation.Semantic proximity Read ↗

Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.Semantic proximity Read ↗

Two modes of FEN1 binding to PCNA regulated by DNA.Semantic proximity Read ↗

Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage.Semantic proximity Read ↗

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.Semantic proximity Read ↗

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.Semantic proximity Read ↗

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.