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Article

Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells.

European journal of immunology - 1 Mar 2005

Ardouin Laurence, Rolink Antonius G, Mura Anne-Marie, Gommeaux Julien, Melchers Fritz, Busslinger Meinrad, Malissen Marie, Malissen Bernard

Abstract excerpt

Following injection into recombinase-activating gene-deficient (Rag1(-/-)) mice, pro-B cells lacking the Pax5 transcription factor (Pax5(-/-)) develop into most major hematopoietic lineages, with the notable exception of B cells. We assessed whether Pax5(-/-) pro-B cells that were also rendered d...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15719364
DOI: 10.1002/eji.200425836

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15719364-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells.PMID 15719364Read ↗

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Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation.Semantic proximity Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.Semantic proximity Read ↗

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The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.Semantic proximity Read ↗

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