Article

C57BL/6 Background Attenuates mHTT Toxicity in the Striatum of YAC128 Mice

2021-11-02

Abstract excerpt

Mouse models are frequently used to study Huntington’s disease (HD). Onset and severity of neuronal and behavioral pathologies vary greatly between HD mouse models, which results from different huntingtin expression levels and different CAG repeat length. HD pathology appears to depend also on strain background of mouse models. Thus, behavioral deficits of HD mice are more severe in the FVB than in the C57BL...

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Literature Corpus work: 11f154ed-1d16-5322-944c-72f0c5242c2c
DOI: 10.20944/preprints202111.0049.v1

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