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Article

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

4 Apr 2005

Abstract excerpt

Huntington disease (HD) is an adult-onset neurodegenerative disease caused by a toxic gain of function in the huntingtin (htt) protein. The contribution of wild-type htt function to the pathogenesis of HD is currently uncertain. To assess the role of wild-type htt in HD, we generated YAC128 mice that do not express wild-type htt (YAC128-/-) but express the same amount of mutant htt as normal YAC128 mice...

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PMID: 15829505
DOI: 10.1093/hmg/ddi147

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Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington diseasePMID 15829505Read ↗

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C57BL/6 Background Attenuates mHTT Toxicity in the Striatum of YAC128 MiceSemantic proximity Read ↗

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington diseaseSemantic proximity Read ↗

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