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Article

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.

Neurobiology of disease - 1 Feb 2006

Graham Rona K, Slow Elizabeth J, Deng Yu, Bissada Nagat, Lu Ge, Pearson Jacqueline, Shehadeh Jacqueline, Leavitt Blair R, Raymond Lynn A, Hayden Michael R

Abstract excerpt

Huntington disease (HD) is a devastating neuropsychiatric disease caused by expansion of a trinucleotide repeat (CAG) in the HD gene. Neuropathological changes include the appearance of N-terminal huntingtin fragments, decreased brain weight and apoptotic neuronal loss in a select subset of neurons located in the striatum. There is still controversy over whether homozygosity for the mutation in HD is associated...

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Source

Identifiers

PMID: 16230019
DOI: 10.1016/j.nbd.2005.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.PMID 16230019Read ↗

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