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Article

The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.

Traffic (Copenhagen, Denmark) - 1 Mar 2007

Sohda Miwa, Misumi Yoshio, Yoshimura Shin-Ichiro, Nakamura Nobuhiro, Fusano Takami, Ogata Shigenori, Sakisaka Shotaro, Ikehara Yukio

Abstract excerpt

The vesicle-tethering protein p115 functions in endoplasmic reticulum-Golgi trafficking. We explored the function of homologous region 2 (HR2) of the p115 head domain that is highly homologous with the yeast counterpart, Uso1p. By expression of p115 mutants in p115 knockdown (KD) cells, we found that deletion of HR2 caused an irregular assembly of the Golgi, which consisted of a cluster of mini-stacked Golgi...

Topics

Adaptor Proteins, Vesicular Transport
Brefeldin A
Endoplasmic Reticulum
Golgi Apparatus
Golgi Matrix Proteins
HeLa Cells
Humans
Membrane Proteins
Mutation
Protein Interaction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Protein Synthesis Inhibitors

Protein Transport

SNARE Proteins

Vesicular Transport Proteins

Source

Identifiers

PMID: 17274799
DOI: 10.1111/j.1600-0854.2006.00530.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17274799-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.PMID 17274799Read ↗

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Golgi CATCHR complexes function as organizing hubs for vesicle tethering and fusionSemantic proximity Read ↗

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