Article
The membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains required for its localization and function.
The Journal of cell biology - 19 Oct 1998
Nelson D S, Alvarez C, Gao Y S, García-Mata R, Fialkowski E, Sztul E
Abstract excerpt
The mammalian protein TAP/p115 and its yeast homologue Uso1p have an essential role in membrane traffic (Nakajima et al., 1991; Waters et al., 1992; Sztul et al., 1993; Rabouille et al.; 1995). To inquire into the site and mechanism of TAP/p115 action, we aimed to localize it and to identify domains required for its function. We show that in interphase cells, TAP/p115 localizes predominantly to the Golgi and to...
Topics
- Acids
- Amino Acid Sequence
- Animals
- Autoantigens
- Biological Transport
- COS Cells
- Carrier Proteins
- Cell Compartmentation
- Cytoplasmic Granules
- Fluorescent Antibody Technique