Article
COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Traffic (Copenhagen, Denmark) - 1 Feb 2013
Kudlyk Tetyana, Willett Rose, Pokrovskaya Irina D, Lupashin Vladimir
Abstract excerpt
Vesicular tethers and SNAREs are two key protein components that govern docking and fusion of intracellular membrane carriers in eukaryotic cells. The conserved oligomeric Golgi (COG) complex has been specifically implicated in the tethering of retrograde intra-Golgi vesicles. Using yeast two-hybrid and co-immunoprecipitation approaches, we show that the COG6 subunit of the COG complex is capable of interacting...
Topics
- Adaptor Proteins, Vesicular Transport
- Binding Sites
- Golgi Apparatus
- HeLa Cells
- Humans
- Mutation
- Protein Binding
- RNA, Small Interfering
- SNARE Proteins
- Transport Vesicles
- Two-Hybrid System Techniques