Golgi inCOGnito: From vesicle tethering to human disease.

doi:10.1016/j.bbagen.2020.129694

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Article

Golgi inCOGnito: From vesicle tethering to human disease.

Biochimica et biophysica acta. General subjects - 1 Nov 2020

D'Souza Zinia, Taher Farhana S, Lupashin Vladimir V

Abstract excerpt

The Conserved Oligomeric Golgi (COG) complex, a multi-subunit vesicle tethering complex of the CATCHR (Complexes Associated with Tethering Containing Helical Rods) family, controls several aspects of cellular homeostasis by orchestrating retrograde vesicle traffic within the Golgi. The COG complex interacts with all key players regulating intra-Golgi trafficking, namely SNAREs, SNARE-interacting proteins, Rabs,...

Topics

Adaptor Proteins, Vesicular Transport
Animals
Biological Transport
Congenital Disorders of Glycosylation
Glycosylation
Golgi Apparatus
Humans
Multiprotein Complexes
Mutation
Protein Interaction Maps
Protein Subunits

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Identifiers

PMID: 32730773
DOI: 10.1016/j.bbagen.2020.129694
PMCID: PMC7384418

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