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Article

Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.

Science (New York, N.Y.) - 2 Feb 2007

Nelson Christopher D, Perry Stephen J, Regier Debra S, Prescott Stephen M, Topham Matthew K, Lefkowitz Robert J

Abstract excerpt

Seven-transmembrane receptor (7TMR) signaling is transduced by second messengers such as diacylglycerol (DAG) generated in response to the heterotrimeric guanine nucleotide-binding protein Gq and is terminated by receptor desensitization and degradation of the second messengers. We show that beta-arrestins coordinate both processes for the Gq-coupled M1 muscarinic receptor. beta-Arrestins physically interact with...

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PMID: 17272726
DOI: 10.1126/science.1134562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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