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Article

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.

Science (New York, N.Y.) - 25 Oct 2002

Perry Stephen J, Baillie George S, Kohout Trudy A, McPhee Ian, Magiera Maria M, Ang Kok Long, Miller William E, McLean Alison J, Conti Marco, Houslay Miles D, Lefkowitz Robert J

Abstract excerpt

Catecholamines signal through the beta2-adrenergic receptor by promoting production of the second messenger adenosine 3',5'-monophosphate (cAMP). The magnitude of this signal is restricted by desensitization of the receptors through their binding to beta-arrestins and by cAMP degradation by phosphodiesterase (PDE) enzymes. We show that beta-arrestins coordinate both processes by recruiting PDEs to activated...

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Share to Arrestins
Share to 3',5'-Cyclic-AMP Phosphodiesterases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Adrenergic beta-Agonists

Share to beta-Arrestins

Share to Cyclic AMP-Dependent Protein Kinases

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

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Share to Receptors, Adrenergic, beta-2

Source

Identifiers

PMID: 12399592
DOI: 10.1126/science.1074683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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