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Article

Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.

Endocrinology - 1 May 2007

Chen Chun-Rong, McLachlan Sandra M, Rapoport Basil

Abstract excerpt

TSH binding to the TSH receptor (TSHR) induces thyrocyte growth and proliferation primarily by activating the adenylyl cyclase signaling pathway. Relative to the other glycoprotein hormone receptors, the TSHR has considerable ligand-independent (constitutive) activity. We describe a TSHR monoclonal antibody (CS-17) with the previously unrecognized property of being an inverse agonist for TSHR constitutive...

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Source

Identifiers

PMID: 17272389
DOI: 10.1210/en.2006-1754

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.PMID 17272389Read ↗

A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain.Semantic proximity Read ↗

Constitutive activities in the thyrotropin receptor: regulation and significance.Semantic proximity Read ↗

TSH receptor monoclonal antibodies with agonist, antagonist, and inverse agonist activities.Semantic proximity Read ↗

The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design.Semantic proximity Read ↗

Constitutive TSH receptor activation as a hallmark of thyroid autonomy.Semantic proximity Read ↗

Thyrotropin receptor-associated diseases: from adenomata to Graves disease.Semantic proximity Read ↗

Mutations in the mouse TSH receptor equivalent to human constitutively activating TSH receptor mutations also cause constitutive activity.Semantic proximity Read ↗

A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity.Semantic proximity Read ↗

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Minireview: Structural and Functional Evolution of the Thyrotropin ReceptorSemantic proximity Read ↗

Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors.Semantic proximity Read ↗

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