Article
A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity.
Thyroid : official journal of the American Thyroid Association - 1 Jul 2008
Sanders Jane, Evans Michele, Betterle Corrado, Sanders Paul, Bhardwaja Anshu, Young Stuart, Roberts Emma, Wilmot Jane, Richards Tonya, Kiddie Angela, Small Kasemsri, Platt Hayley, Summerhayes Sara, Harris Rebecca, Reeve Magnus, Coco Graziella, Zanchetta Renato, Chen Shu, Furmaniak Jadwiga, Smith Bernard Rees
Abstract excerpt
BACKGROUND: Human monoclonal autoantibodies (MAbs) are valuable tools to study autoimmune responses. To date only one human MAb to the thyrotropin (TSH) receptor (TSHR) with stimulating activity has been available. We now describe the detailed characterization of a blocking type human MAb to the TSHR. METHODS: A single heterohybridoma cell line was isolated from the peripheral blood lymphocytes of a patient with...
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