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Article

Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations.

Methods in enzymology - 1 Jan 2010

Lado-Abeal Joaquin, Quisenberry Leah R, Castro-Piedras Isabel

Abstract excerpt

Thyroid stimulating hormone receptor (TSHR) is a guanine nucleotide-binding protein-coupled seven-transmembrane-domain receptor that controls the differentiation, growth, and function of the thyroid gland through stimulation of adenylyl cyclase and phospholipase C pathways. Thyroid stimulating hormone (TSH) is the main TSHR ligand, and unliganded receptor remains silent due to the interaction of its large...

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Source

Identifiers

PMID: 21036242
DOI: 10.1016/B978-0-12-381298-8.00019-8

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations.PMID 21036242Read ↗

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