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Article

Thyrotropin receptor-associated diseases: from adenomata to Graves disease.

The Journal of clinical investigation - 1 Aug 2005

Davies Terry F, Ando Takao, Lin Reigh-Yi, Tomer Yaron, Latif Rauf

Abstract excerpt

The thyroid-stimulating hormone receptor (TSHR) is a G protein-linked, 7-transmembrane domain (7-TMD) receptor that undergoes complex posttranslational processing unique to this glycoprotein receptor family. Due to its complex structure, TSHR appears to have unstable molecular integrity and a propensity toward over- or underactivity on the basis of point genetic mutations or antibody-induced structural changes....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Structure, Tertiary

Share to Receptors, Thyrotropin

Share to Thyroid Gland

Source

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Identifiers

PMID: 16075037
DOI: 10.1172/JCI26031
PMCID: PMC1180562

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thyrotropin receptor-associated diseases: from adenomata to Graves disease.PMID 16075037Read ↗

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Thyroid-stimulating hormone receptor and its role in Graves' disease.Semantic proximity Read ↗

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Novel insights on thyroid-stimulating hormone receptor signal transduction.Semantic proximity Read ↗

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action.Semantic proximity Read ↗

Constitutive TSH receptor activation as a hallmark of thyroid autonomy.Semantic proximity Read ↗

Constitutive activities in the thyrotropin receptor: regulation and significance.Semantic proximity Read ↗

Minireview: Structural and Functional Evolution of the Thyrotropin ReceptorSemantic proximity Read ↗

Understanding the thyrotropin receptor function-structure relationship.Semantic proximity Read ↗

[Disorders caused by mutations of the thyrotropin receptor].Semantic proximity Read ↗

The genetics of the thyroid stimulating hormone receptor: history and relevance.Semantic proximity Read ↗

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