Article
The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design.
Endocrinology - 1 Sept 2000
Zhang M, Tong K P, Fremont V, Chen J, Narayan P, Puett D, Weintraub B D, Szkudlinski M W
Abstract excerpt
Among glycoprotein hormone receptors the TSH receptor (TSHR) is the most susceptible to constitutive activation by mutations in various regions of the molecule, including mutations in the extracellular domain (ECD) and extracellular loops of the transmembrane domain (TMD). To understand the role of the ECD in TSHR activation we have tested several TSHR constructs with major deletions of the ECD. Previous studies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.