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Article

Estrogen receptor alpha haplotypes and breast cancer risk in older Caucasian women.

Breast cancer research and treatment - 1 Dec 2007

Wang Jun, Higuchi Russell, Modugno Francesmary, Li Jia, Umblas Nanette, Lee Jocelyn, Lui Li-Yung, Ziv Elad, Tice Jeffery A, Cummings Steven R, Rhees Brian

Abstract excerpt

Life-long exposure to estrogen is an established risk factor for breast cancer development. The underlying mechanism has been suggested to be the binding of estrogen-to-estrogen receptors in mammary tissue, which in turn promotes the proliferation and differentiation of breast tissue. Polymorphisms and haplotypes in estrogen receptor alpha (ESR1) have been reportedly associated with breast cancer risk; however,...

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Source

Identifiers

PMID: 17268813
DOI: 10.1007/s10549-007-9497-8

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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